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KMID : 0378019840270110075
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New Medical Journal
1984 Volume.27 No. 11 p.75 ~ p.81
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Male Infertility
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Abstract
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Some investigators suggest that the pancreatic proteinase kallikrein plays an important role in the regulation of spermatozoal motility: Particularly, oral kallikrein therapy exerted a favorable effect on sperm motility in oligozoospermia and asthenozoospermia.
We have, carried out a similar clinical investigation of the efficacy of kallikrein(Kallina), taken orally 60 KU per day for 3-9 months, on the quantitative and qualitative increase of´ motile spermatozoa in normogonadotropic infertile males with 15 idiopathic oligozoospermia (less than 20x106/ml, oligozoospermia group) and 15 idiopathic asthenozoospermia(less than 20% of sperm motility, asthenozoospermia qroup). In addition to these patients, 10 idiopathic asthenozoospermia entered the study as control placebo treatment group. Semen analyses were repeated monthly before, during and after the treatment.
Sperm motility was increased only in 2 patients (20%) out of the 10 placebo treatment control group, but no pregnancy occurred 3 months after placebo treatment. Number of spermatozoa increased more than 30% of basic levels (over 30x106/ml) in the 5 patients (33%) and pregnancy occurred in the 3 patients (20%) out of the 15 patients with idiopathic oligozoospermia after the kallikrein therapy. In these 5 patients responded, the sperm concentration changed from 14.5x106/ml to 38.8x106/ml. Motility and viability of spermatozoa improved more than 20% in the 6 patients(40%) and pregnancy occurred in the 2 patients (13%) out of the 15 idiopathic asthenozoospermia after the therapy. In these 6 patients improved, the sperm motility changed from 16.0% to 46.6%. No remarkable side effect was detected.
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KEYWORD
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